Research into the causes, detection, diagnosis, and treatment of kidney cancer is now being done at many medical centers, university hospitals, and other institutions across the nation.
Genetics
Scientists are studying several genes that seem to play a part in changing normal kidney cells into renal cell carcinoma (RCC).
For example, problems with the VHL tumor suppressor gene are found in most clear cell RCCs. This allows other genes such as the hypoxia-inducible factor (HIF) gene to be activated when they shouldn’t be, which drives a cell toward being cancerous. Some newer treatments focus on attacking this cellular pathway.
Researchers now also have a better idea of the gene changes responsible for some other forms of RCC. Doctors are trying to determine which treatments are most likely to be effective for certain types of RCC. This information can also be used to develop new treatments........READ MORE
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